CORO6 Promotes Cell Growth and Invasion of Clear Cell Renal Cell Carcinoma via Activation of WNT Signaling

Renal cell carcinoma (RCC) constitutes the most lethal type of genitourinary cancer. Understanding RCC tumor biology helps to identify novel targets and develop directed treatments for patients with this Analysis from both The Cancer Genome Atlas Kidney Clear Cell Carcinoma dataset our samples demonstrated that expression level CORO6 was significantly higher in than normal kidney tissues, its highly associated stage grade. Importantly, an independent predictor metastasis overall survival patients. Our line data also confirmed knockdown could suppress growth as well migration invasion. depletion led cycle arrest at G0/G1 phase caused apoptosis. Further, mechanistic dissection showed mediated growth, invasion relied on WNT signaling. Moreover, vivo suggested indeed suppressed growth. Overall, study defines oncogenic role progression provides a rationale developing CORO6-targeted therapies improved treatment